A MOLECULAR-PATHOLOGICAL APPROACH TO MURINE SENILE AMYLOIDOSIS - SERUM PRECURSOR-APOLIPOPROTEIN-A-II VARIANT (PRO5-]GLN) PRESENTS ONLY IN THE SENILE AMYLOIDOSIS-PRONE SAM-P/1 AND SAM-P/2 MICE

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  • 1 July 1987
    • journal article
    • research article
    • Vol. 57  (1) , 65-70
Abstract
Murine apolipoprotein (apo) A-II is a serum precursor of murine senile amyloid protein. We determined the primary structures of apo A-II in accelerated senescence-prone mice (SAM-P) characterized by a high frequency of age-associated systemic amyloidosis and accelerated senescence-resistance mice (SAM-R) in which senile amyloidosis occurred with a low incidence. Apo A-II variant (Pro5 .fwdarw. Gln) was found to be present only in the serum of SAM-P and not in that of SAM-R or other random bred slc: ICR mice. The apo A-II variant in the serum of SAM-P is identical to the murine senile amyloid fibril protein (ASsam) derived from amyloid-deposited tissues of SAM-P. These findings proved that apo A-II deposits in tissues without degradation and this mutation (Pro5.fwdarw.Gln) probably have significant effects on the structure and function of apo A-II and would play a critical role in murine senile amyloidogenesis.