Hsp70 genes are linked to the Xenopus major histocompatibility complex
- 1 January 1994
- journal article
- Published by Springer Nature in Immunogenetics
- Vol. 39 (1) , 1-7
- https://doi.org/10.1007/bf00171790
Abstract
Some of the inducible forms of the heat shock protein 70 (Hsp70) gene family are encoded in the class III region of the major histocompatibility complex (MHC) of mammals. This study was undertaken to determine whether Hsp 70 genes are linked to the MHC of Xenopus, an amphibian last sharing a common ancestor with mammals 300–350 million years ago. Segregation analyses involving seven haplotypes demonstrated the linkage of two or three inducible Hsp70 genes to the frog MHC. Another Hsp70 gene is not closely linked to the MHC. We conclude that the physical association of MHC class I and class II genes with Hsp70 genes is ancient.Keywords
This publication has 43 references indexed in Scilit:
- Sea Urchin Egg Receptor for Sperm: Sequence Similarity of Binding Domain and hsp70Science, 1993
- Thymic selection: a matter of life and deathImmunology Today, 1992
- Effect of polymorphism of an MHC-linked transporter on the peptides assembled in a class I moleculeNature, 1992
- Simplified mammalian DNA isolation procedureNucleic Acids Research, 1991
- Localization of a mouse heat shock Hsp70 gene within the H-2 complexImmunogenetics, 1990
- The Major Histocompatibility Complex of FrogsImmunological Reviews, 1990
- Localization of heat shock protein 70 genes inside the rat major histocompatibility complex close to class III genesImmunogenetics, 1989
- Acquisition of the heat-shock response and thermotolerance during early development of Xenopus laevisDevelopmental Biology, 1985
- Immunoglobulin heavy chain binding proteinNature, 1983
- The expression of antibody diversity in natural and laboratory-made polyploid individuals of the clawed toad XenopusImmunogenetics, 1982