In Vitro Oxygen Consumption of Tissues From Normal and Adrenalectomized Rats

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Abstract
The 02 utilization by whole brain homogenates and brain cortex, liver and kidney slices were investigated in normal and adrenalectomized rats by the direct method of Warburg. No difference could be demonstrated between the 2 groups with homogenates prepared with or without added glucose, or at 37[degree], 30[degree], and 25[degree]C. Values of [mu] calculated from the 02 uptake over the 12[degree] temp. range were identical. Ability to utilize glucose after depletion of the endogenous stores was not impaired by adrenalectomy. Tissue slices from 60- and 28-day-old rats failed to demonstrate any significant diminution of O2 utilization following adrenalectomy. Assays of cytochrome oxidase and succinic dehydrogenase showed no alteration in their activities.

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