EFFECT OF TEMPERATURE ON THE OXYGEN CONSUMPTION OF BRAIN TISSUE

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Abstract
Mean values of the O2 consumption of cerebral cortex slices from adult albino rats were detd. at graded temps. within the limits 0.2[degree]C.-47.5[degree]C. Most observations were made below 40[degree]C, 345 animals being used. The standard deviation of the distribution and the standard error of the mean were calculated for the values of O2 consumption at each temp. used in the range 0.2[degree]C.-37.5[degree]C. The graph of log O2 consumption as a function of temp. in degrees C. was approx. linear in the range 10[degree]C.-37.5[degree]C. The van''t Hoff temp. coefficient, Q10, for O2 consumption in this temp. range was 2.13. At 40[degree] C. and above, the rate of O2 uptake diminished with time, the more rapidly the higher the temp. There was complete recovery of the initial capacity for O2 consumption when the cortex slices were returned to 37.5[degree]C. even after 3 hrs. at 40[degree]C, but at 40.8[degree]C. there was some irreversible loss of this capacity after 30 mins. This loss was progressively greater with increase in temp., exposure time, or both. However, there was a definite limit to the diminution in O2 consumption at least for temps. up to 47.5[degree]C. and exposure times up to 2 hrs. The steady rate of O2 consumption attained under such conditions amounted to about 10% of the rate of O2 uptake at 37.5[degree]C. There was no indication of the accumulation of a substance capable of inhibiting the O2 uptake of fresh brain tissue when brain slices or brei were incubated for 70 mins. at 47.5[degree]C.

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