POSSIBLE CLQ BYPASS LOOP ACTIVATION IN THE HEMOLYTIC UREMIC SYNDROME
- 1 January 1979
- journal article
- research article
- Vol. 35 (1) , 107-111
Abstract
Ultrastructural and immunofluorescent microscopic studies were performed on renal tissue obtained from 9 patients during thd acute and convalescent phase of the hemolytic uremic syndrome (HUS). All had glomerular deposits of Ig[immunoglobulin]M in the absence of circulating immune complexes. This was associated with deposition of C1q [a fragment of complement component 1] during the acute phase and properdin and C3 during the convalescent phase. C4 was consistently absent. Since such a pattern of C deposition does not fulfill criteria for alternate or classical pathway activation, the possibility of C1q bypass loop activation by IgM is suggested.This publication has 12 references indexed in Scilit:
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