The inheritance in the rat of the capacity to eliminate nicotinamide methochloride

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Abstract
Two strains of pure-bred rats, one albino and one black hooded, with low and high nicotinamide methochloride elimination and response to extra dietary nicotinamide, respectively, were cross-bred in order to test whether the amt. of nicotinamide methochloride elimination and the response were genetically controlled. For this purpose nicotinamide methochloride output and response of the offspring of several generations of the cross-breds and black crossings were examined, and related to coat color. Output and response are inherited multifactorially. The 2 sets of genes controlling the 2 measurements have some, but not all, members in common. The data provide no evidence of a direct effect of sex, or that sex-linked genes play an important part in the heredity of output or response. One of the genes controlling output and one of those controlling response (possibly the same gene) are linked with the agouti gene.