Linkage disequilibrium, genetic distance and evolutionary distance under a general model of linked genes or a part of the genome
- 1 February 1982
- journal article
- research article
- Published by Hindawi Limited in Genetics Research
- Vol. 39 (1) , 63-77
- https://doi.org/10.1017/s0016672300020747
Abstract
Summary: A general model of linked genes or a part of a genome is proposed which enables us to study various problems in molecular population genetics in a unified way. Several formulae with special reference to the linkage disequilibrium and genetic distance are derived for neutral mutations in finite populations, based on the method of diffusion equations. It is argued that the model and formulae are useful particularly when observations are made in terms of DNA sequence.This publication has 35 references indexed in Scilit:
- A mathematical model of extranuclear genes and the genetic variability maintained in a finite populationGenetics Research, 1981
- Estimating evolutionary distance from restriction maps of mitochondrial DNA with arbitrary G+C contentJournal of Molecular Evolution, 1981
- Linkage disequilibrium between amino acid sites in immunoglobulin genes and other multigene familiesGenetics Research, 1980
- A simple method for estimating evolutionary rates of base substitutions through comparative studies of nucleotide sequencesJournal of Molecular Evolution, 1980
- Inter- and intraspecific variation in restriction maps of Drosophila mitochondrial DNAsNature, 1979
- Mathematical model for studying genetic variation in terms of restriction endonucleases.Proceedings of the National Academy of Sciences, 1979
- Linkage disequilibrium due to random genetic driftGenetics Research, 1969
- Linkage disequilibrium in finite populationsTheoretical and Applied Genetics, 1968
- Inbreeding in artificial selection programmesGenetics Research, 1961
- A Mathematical Theory of Natural Selection. Part VIII. Metastable PopulationsMathematical Proceedings of the Cambridge Philosophical Society, 1931