Evaluation of the predictive capability of an in-vitro model of colonisation resistance toClostridium difficileinfection
Open Access
- 1 January 1988
- journal article
- research article
- Published by Taylor & Francis in Microbial Ecology in Health & Disease
- Vol. 1 (1) , 61-64
- https://doi.org/10.3109/08910608809140181
Abstract
Caecal emulsions prepared from hamsters pre-treated with clindamycin or ampicillin supported growth of, and cyto-toxin production by, Clostridium difficile, whereas those from aztreonam or temocillin pre-treated or untreated hamsters did not. These findings were predictive of outcome of infection with C. difficile as clindamycin and ampicillin pre-treated animals became colonized and died whereas the other animals did not.Keywords
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