Production of Con A-induced helper T cell replacing factor requires a T cell and an Ia-positive non-T cells.
Open Access
- 1 January 1980
- journal article
- research article
- Published by Oxford University Press (OUP) in The Journal of Immunology
- Vol. 124 (1) , 437-444
- https://doi.org/10.4049/jimmunol.124.1.437
Abstract
Evidence is presented that indicates that two cells are required for the production of Con A-induced, helper T cell replacing factor. The factor production involves both a T cell and an IA,IE/C-positive non-T cell. The T cell and the Ia-positive cell need not be H-2 compatible. Limiting dilution analyses suggested that the Ia-positive cell is limiting in normal spleen. A hypothesis is put forward that the activation of T cells by Con A may involve "gluing" normally specific, functional T cells to the Ia expressing cells with which they would normally interact in antigen-specific activation.This publication has 16 references indexed in Scilit:
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