Asymmetric total synthesis of (–)-podophyllotoxin
- 1 January 1993
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Chemical Communications
- No. 15,p. 1200-1201
- https://doi.org/10.1039/c39930001200
Abstract
(–)-Podophyllotoxinof 98% optical purity is synthesised in eight steps and in 15% overall yield from the pyrone 2 and the chiral dienophile 3.Keywords
This publication has 10 references indexed in Scilit:
- Synthesis of Podophyllotoxin and Related CompoundsSynthesis, 1992
- Studies on the constituents of the seeds of Hernandia ovigera L. VIII. Syntheses of (.+-.)-desoxypodophyllotoxin and (.+-.)-.BETA.-peltatin-A methyl ether.CHEMICAL & PHARMACEUTICAL BULLETIN, 1991
- Enantioselective total synthesis of (−)-epipodophyllotoxin and (−)-podophyllotoxinTetrahedron, 1991
- Asymmetric Diels-Alder reactions with 5-menthyloxy-2-(5H)-furanoneTetrahedron: Asymmetry, 1991
- Asymmetric synthesis of declines and hexahydroindanesTetrahedron Letters, 1990
- Asymmetric total synthesis of (−)-deoxypodophyllotoxinTetrahedron Letters, 1990
- Synthesis of enantiomerically pure bi- and tricyclic lactones with quaternary chiral centersTetrahedron Letters, 1989
- Asymmetric total synthesis of (-)-podophyllotoxinJournal of the American Chemical Society, 1988
- Regioselective suprafacial 1,5-hydrogen shifts in o-quinodimethanes; a route to 4-deoxypodophyllotoxinJournal of the Chemical Society, Chemical Communications, 1988
- Synthesis of podophyllum lignans via an isolable o-quinonoid pyroneJournal of the Chemical Society, Chemical Communications, 1987