PHYSIOLOGICAL VARIATIONS IN THE CARDIAC OUTPUT OF MAN

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Abstract
A study was made of the cardiac output, pulse rate, blood pressure and basal metabolism of 51 individuals in the resting, basal condition. The results indicated that the cardiac output of normal men and women is a function of their surface area and can be predicted with a high degree of accuracy. The cardiac output per g.m. of body surface was found to be 2.2[plus or minus]+0.3, with an average deviation from the mean of only 5%. Expressed in this way the results indicate a lower cardiac output for man than has been previously reported by other observers. This is attributed to the stringent conditions of absolute rest, the avoidance of any disturbing factors, and the high accuracy of the determinations. Under such conditions, determinations of the cardiac output may be treated in the same manner as metabolic measurements. The arterio-venous O difference of normal young individuals is the most constant of all the variables relating to the circulatory system. Its value is 60 [plus or minus]+ 5 cc. per liter of blood, which corresponds to an O utilization of about 1/3.

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