Elevated 7S Immunoglobulin and Acute Phase Proteins in Adjuvant-Injected Chickens

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Abstract
Injection of chickens with Freund''s complete or incomplete adjuvant supplemented with Bordetella pertussis or Nocardia rubra induced greatly increased serum levels of 7S immunoglobulin [Ig] and proteins with .alpha.-, .beta.-, and .gamma.-mobility in electrophoresis. The serum protein changes were correlated with the development of delayed hypersensitivity and the formation of a large allergic granuloma. The 7S Ig was considered nonspecific since it was not adsorbed with the bacterial cells. The .alpha.-, .beta.-, and .gamma.-mobility proteins were identified as acute phase proteins as they also were induced by injection of chickens with turpentine-oil; increased serum levels of 7S Ig were not similarly increased. A cellular mechanism for these phenomena is described.