Production of Gamma Interferon in Mls Disparate Interactions

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Abstract
The marine T-cell clone E11 isolated from a primary H-2k histocompatible one-way mixed lymphocyte culture of B10.BR anti C3H/Tif spleen cells was used to study multidirectional interactions in strong stimulatory Mls disparate responses. Several parameters have recently been studied, and proliferation of T cells upon stimulation by macrophages or B cells of Mls-disparate stimulator cells, induction of differentiation of B cells of stimulator strains but inhibition of their macrophage differentiation, and the inhibition by E11 T cells of the production of a mitogenic mediator by Mls-disparate spleen cells have been found. As shown in this paper, these phenomena can be explained by an Mlsa, d, c specific induction of gamma-interferon(IFN-γ) production in the responder B10.BR (Mlsb) E11 T cells. It is suggested that (IFN-γ), as a regulator of feedback mechanisms, plays a critical role in Mls disparate T-cell stimulation.