Metabolism of Acetate by Isolated Perfused Dog Gastrocnemius Investigated with C13-Carboxyl-Labeled Acetate

Abstract
Under the conditions employed 24-48% of the respiratory CO2 recovered from stimulated muscle was calculated to have been derived from the administered C13-carboxyl labeled acetate on the assumption that both carbons of the acetate molecule were oxidized at equal rates. In un-stimulated muscles 15-32% of the CO2 was derived from the acetate oxidation. Less than one carbon atom out of 100 in the muscle glycogen was derived from the administered acetate.