Tumor Immunity in Rats Immunized with Rat Carcinoembryonic Antigen
- 1 January 1986
- journal article
- research article
- Published by S. Karger AG in International Archives of Allergy and Immunology
- Vol. 80 (2) , 152-156
- https://doi.org/10.1159/000234044
Abstract
Active immunization of rats with an emulsion consisting of Freund’s complete adjuvant (FCA) and an extract of rat tumor containing carcinoembryonic antigen (CEA) induced clear-cut protection from growth of the syngeneic CEA-positive tumor, RCA-1. No protection was observed in rats treated with FCA alone nor was there protection against a tumor that had no serologically detectable CEA. The results suggested that the tumor immunity exhibited by the immunized rats was mediated by an immune response specific for rat CEA. It was shown further that multiparous rats were more resistant to growth of RCA-1 tumor than nulliparous rats. This suggested that immunization against rat CEA, which is an oncofetal antigen, may occur during pregnancy.This publication has 2 references indexed in Scilit:
- Induction of Antibodies in Rats to a Rat Carcinoembryonic AntigenInternational Archives of Allergy and Immunology, 1985
- Detection of antibodies to embryonic antigens in sera of multiparous or colon tumor-bearing rats by a new indirect immunofluorescence assayInternational Journal of Cancer, 1977