Influence of lodgement site on the proliferation of metastases of Walker 256 carcinoma in the rat

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Abstract
The growth of s.c. Walker 256 carcinoma was found to be independent of secondary growths induced by i.v. injection. Tumour cells injected i.v. lodged mainly in the lungs, with small clusters of cells in the lymph nodes. The rate of cellular proliferation of these secondary growths of Walker carcinoma was significantly higher than that observed in the s.c. tumour. In addition, host lung tissue was found to inhibit the development of metastases, and it is postulated that the host tissue may produce a diffusible inhibitor and that differences in the effectiveness of these humoral factors may account, in part, for locational differences in tumour growth patterns.