Efficacy of Difloxacin in Growing Broiler Chickens for the Control of Infection due to Pathogenic Mycoplasma gallisepticum

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Abstract
Summary: Chickens 14 days old were experimentally inoculated with Mycoplasma gallisepticum (MG) R‐P10 strain. After development of respiratory symptoms, birds were left unmedicated or medicated for 5 consecutive days with Difloxacin 5, 7.5 or 10 mg/kg body weight per day or Enrofloxacin at the dose level of 10 mg/kg body weight per day. Evaluation of efficacy was based on body weight, symptoms, post‐mortem findings, re‐isolation of MG and serology. Results indicated that under the conditions of this experiment, treatment with 7.5 mg Difloxacin per kg body weight for 5 days was already effective against pathogenic MG infection. The dose of 10 mg/kg Difloxacin was equally effective as a dose of 10 mg/kg Enrofloxacin in treating respiratory symptoms.