STUDIES ON THE METABOLISM OF MYCOBACTERIUM TUBERCULOSIS III

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Abstract
The growth rate of M. tuberculosis var. hominis in the presence of various intermediates of the dissimilation of glucose to pyruvic acid was investigated. Gluconic acid and glucose stimulated the growth of the organisms to an approx. similar degree. In contrast, the various substrates which are involved in the glycolytic process did not support growth appreciably. Pyruvic acid and lactic acid, end products in the oxidation of glucose, stimulated the rate of growth to a greater degree than did glucose, suggesting perhaps the presence of a more efficient terminal metabolic process for this strain.