Effects of indole-3-acetic acid on croton oil- and arachidonic acid-induced mouse ear edema
- 1 September 1995
- journal article
- Published by Springer Nature in Inflammation Research
- Vol. 44 (9) , 372-375
- https://doi.org/10.1007/bf01797863
Abstract
The indole-3-acetic acid (IAA) is a plant growth hormone (auxin) being considered as a tryptophan metabolite in animals. The main purpose of this work was to verify IAA's topical anti-inflammatory action using croton oil- or arachidonic acid-induced mouse ear edema, in comparison to known anti-inflammatory agents. IAA antioxidant activity was also verified by measuring the inhibition of brain homogenate lipid peroxidation with the thiobarbituric acid reactive substances (TBARS) test. IAA inhibited the action of both croton oil- and arachidonic acid-induced edema in a dose-dependent manner (4.0 µmoles IAA inhibited 75.8% in croton oil and 82.5% in arachidonic acid induced ear edema). Both IAA (5.3 mM) and indomethacin (8.0 mM) inhibited TBARS formation. Data suggest that IAA exhibits antiinflammatory effect possibly by its antioxidant activity.Keywords
This publication has 62 references indexed in Scilit:
- Pharmacological modification of 12-O-tetradecanoylphorbol-13-acetate induced inflammation and epidermal cell proliferation in mouse skinInflammation Research, 1988
- The iron-binding and hydroxyl radical scavenging action of anti-inflammatory drugsXenobiotica, 1988
- Modulation by phorbol myristate acetate of arachidonic acid release and leukotriene synthesis by human polymorphonuclear leukocytes stimulated with A23187Biochemical and Biophysical Research Communications, 1986
- Doxorubicin-dependent lipid peroxidation at low partial pressures of O2Journal of Free Radicals in Biology & Medicine, 1985
- Modulation of mouse ear edema by cyclooxygenase and lipoxygenase inhibitors and other pharmacologic agentsInflammation Research, 1985
- In vitro inactivation of the neurotoxic action of β-bungarotoxin by the marine natural product, manoalideCellular and Molecular Life Sciences, 1984
- Antioxidation theory of non-steroidal anti-inflammatory drugs based upon the inhibition of luminol-enhanced chemiluminescence from the myeloperoxidase reactionInflammation Research, 1982
- Early prostaglandin E synthesis is an obligatory event in the induction of cell proliferation in mouse epidermis in vivo by the phorbol ester TPABiochemical and Biophysical Research Communications, 1980
- Prostaglandin E and F levels in mouse epidermis are increased by tumor-promoting phorbol estersBiochemical and Biophysical Research Communications, 1979
- Chemotactic factor‐induced generation of superoxide radicals by human neutrophilsArthritis & Rheumatism, 1979