Thymopentin (TP-5) potency in vivo is enhanced by slow infusion

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Abstract
The in vivo activity of thymopentin [which induces seletive T cell differentiation and is involved in immunoregulation] in guinea pigs was assessed electromyographically 18 h after i.v. or s.c. injections or infusions ranging over varying periods of time. The lowest threshold dose required to establish a positive effect was obtained with a 30-60 min i.v. infusion (0.38-0.75 .mu.g/kg) and 5X this dose with 30 min s.c. infusion, 10X this dose with 10 min i.v. or s.c. infusion, 200X this dose with bolus i.v. injection and 400X this dose with bolus s.c. injection were needed. The marked increase of potency of thymopentin with infusion should be considered in designing clinical regimens.