PHARMACOKINETICS OF THERAPEUTIC DOSES OF ISOTOPICALLY LABELED PLATINUM ANTI-TUMOR AGENTS IN THE MOUSE AND RAT

  • 1 January 1983
    • journal article
    • research article
    • Vol. 67  (3) , 245-252
Abstract
The pharmacokinetics of the antitumor agents ethylenediamine platinum dichloride and cisplatin were investigated in mice bearing plasmacytoma ADJ PC6 after therapeutic doses of these agents, labeled either with 191Pt or in the ligand with 14C. The distribution of the radioactive labels was estimated in tumor, kidney, liver, and intestine in treated animals from 1 h to 15 days after administration. The 2 labels, on ligand and on Pt, were equivalent only in some cases with respect to the total radioactivity within a tissue. Patterns of isotope distribution varied with time and tissue and suggested that the metal-ligand bond was dissociated as early as 1 h after administration.