Control of A Double Helix DNA Assembly by Use of Cross-Linked Oligonucleotides
- 17 October 2003
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of the American Chemical Society
- Vol. 125 (45) , 13654-13655
- https://doi.org/10.1021/ja036752l
Abstract
Disulfide cross-linked oligonucleotides for connecting two DNA double helixes have been designed, synthesized, and characterized. Employing these cross-linked oligonucleotides, two double helixes can be arranged side by side, and the orientations can be controlled both in parallel and antiparallel ways by addition of a specific complementary DNA strand.Keywords
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