Serotonergic conversion of MPTP and dopaminergic accumulation of MPP+
- 23 September 1985
- journal article
- Published by Wiley in FEBS Letters
- Vol. 189 (2) , 225-230
- https://doi.org/10.1016/0014-5793(85)81028-0
Abstract
[3H]MPP+ had lower K m and higher V max values for its accumulation in rat brain synaptosomes than did [3H]MPTP. The kinetic parameters favored the uptake of [3H]MPP+ in the striatum to that in hypothalamus, whereas they were equally favorable for the uptake of [3H]MPTP in both regions. Hypothalamic uptake of [3H]MPTP and [3H]MPP+ was inhibited by desipramine, imipramine, norepinephrine, and serotonin. Striatal uptake of [3H]MPP+ and [3H]MPTP was blocked by nomifensine and dopamine. These results support the concept that MPTP accumulates in serotonergic neurons where it is oxidized by monoamine oxidase B to MPP+, which is released and then is selectively accumulated in dopaminergic neurons via the dopamine uptake system.Keywords
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