HLA antigens in inflammatory bowel disease.

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Abstract
HLA antigens were studied in 60 patients with ulcerative colitis, 10 with Crohn''s disease and 120 healthy Japanese controls. HLA typing was performed by the microdroplet lymphocyte cytotoxicity test. B5 was recognized in 62% of the patients with ulcerative colitis and in 40% of controls (P < 0.01). In these patients, B7 was decreased in incidence (P < 0.05); there was the highest relative risk-value [R.R.] for A3 (R.R. = 6.3). When the patients were classified into 2 groups and proctitis group, B5 was recognized in 65% of the patients with left-sided colitis or total colitis; this increase was statistically significant. No significant difference in the incidence of B5 was recognized between the patients with proctitis and controls, probably because the number of patients studied was too small for evaluation. In the patients with Crohn''s disease, B27 was recognized in 1 patient, showing an increase in incidence (P < 0.001), although the number of patients studied was very small.
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