An RNA Polymerase II Transcription Factor Shares Functional Properties with Escherichia coli σ 70
- 22 June 1990
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 248 (4962) , 1550-1553
- https://doi.org/10.1126/science.2193400
Abstract
A mammalian transcription factor, which, along with other factors, is essential for accurate initiation of transcription from promoters by RNA polymerase II, has been found to regulate the interaction of polymerase and DNA. This factor, designated beta gamma, drastically reduces the affinity of RNA polymerase II for free DNA containing either promoter or nonpromoter sequences. In this respect, beta gamma functions as does the bacterial transcription initiation factor sigma 70, which expedites the binding of Escherichia coli RNA polymerase to promoters in part by accelerating dissociation of the polymerase from nonpromoter sites in DNA.This publication has 40 references indexed in Scilit:
- Structure and associated DNA-helicase activity of a general transcription initiation factor that binds to RNA polymerase IINature, 1989
- A general transcription factor forms a stable complex with RNA polymerase B (II)Published by Elsevier ,1987
- Interaction of a gene-specific transcription factor with the adenovirus major late promoter upstream of the TATA box regionCell, 1985
- A drosophila RNA polymerase II transcription factor binds to the regulatory site of an hsp 70 geneCell, 1984
- Isolation of transcription factors that discriminate between different promoters recognized by RNA polymerase IICell, 1983
- Formation of stable preinitiation complexes between eukaryotic class B transcription factors and promoter sequencesNature, 1983
- Mechanism of RNA polymerase II-specific initiation of transcription in vitro: ATP requirement and uncapped runoff transcriptsCell, 1982
- 5 Eukaryotic RNA PolymerasesPublished by Elsevier ,1982
- The Selectivity of TranscriptionAnnual Review of Biochemistry, 1974
- Studies of the binding of Escherichia coli RNA polymerase to DNAJournal of Molecular Biology, 1972