Structure and associated DNA-helicase activity of a general transcription initiation factor that binds to RNA polymerase II
- 1 October 1989
- journal article
- Published by Springer Nature in Nature
- Vol. 341 (6241) , 410-414
- https://doi.org/10.1038/341410a0
Abstract
RAP30/74 is a heteromeric general transcription initiation factor which binds to RNA polymerase II. Here we report that preparations of RAP30/74 contain an ATP-dependent DNA helicase whose probable function is to melt the DNA at transcriptional start sites. The sequence of the RAP30 subunit of RAP30/74 indicates that RAP30 may be distantly related to bacterial sigma factors.Keywords
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