Inhibition of Adenosine 3', 5'-Cyclic Monophosphate Phosphodiesterase by Flavonoids from Licorice Roots and 4-Arylcoumarins

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Abstract
Isoliquiritigenin, glabridin, licoarylcoumarin and licoricidin were identified as strong inhibitors of adenosine 3', 5'-cyclic monophosphate (cAMP) phosphodiesterase in waste materials which were obtained during the industrial extraction of glycyrrhizin from licorice roots. The structure-activity relationships of 12 flavonoids from licorice roots and 34 4-arylcoumarins were studied. In 4-arylcoumarins, 5, 7-dihydroxy derivatives were generally highly inhibitory towards cAMP phosphodiesterase.