Inhibitors of cyclic adenosine monophosphate phosphodiesterase in Polygala tenuifolia.

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Abstract
CAMP phosphodiesterase inhibitors contained in P. tenuifolia were identified as saponins and oleic acid. The concentrations of onjisaponins E, F and G required to give 50% inhibition (IC50) were of the same order as that of papaverine. A kinetic study revealed that onjisaponin F acts noncompetitively against cAMP phosphodiesterase, like papaverine. Onjisaponin F exhibited a prolongation effect on hexobarbital sleeping time in mice.