cGMP and cAMP inhibit tension development in skinned coronary arteries
- 1 July 1984
- journal article
- research article
- Published by Springer Nature in Pflügers Archiv - European Journal of Physiology
- Vol. 401 (3) , 277-280
- https://doi.org/10.1007/bf00582596
Abstract
The effects of physiological concentrations of cGMP and cAMP on tension development in skinned coronary arteries (Triton X-100) were studied. cGMP inhibited tension elicited at intermediate Ca2+ concentrations at pH 7.0 but not at more acidic or alkaline pH values. cAMP, on the other hand, decreased submaximal tension development independent of pH (from pH 6.5 to pH 7.2). Neither nucleotide affected tension development at maximally activating Ca2+ concentrations.This publication has 32 references indexed in Scilit:
- Endothelium-dependent relaxation in rat aorta may be mediated through cyclic GMP-dependent protein phosphorylationNature, 1983
- Skinned coronary smooth muscle: Calmodulin, calcium antagonists, and cAMP influence contractilityBasic Research in Cardiology, 1983
- cGMP‐dependent protein kinase decreases calcium sensitivity of skinned cardiac fibersFEBS Letters, 1982
- Intracellular Ca release in skinned smooth muscle.The Journal of general physiology, 1982
- Vascular smooth muscle. Calmodulin and cyclic AMP-dependent protein kinase after calcium sensitivity in porcine carotid skinned fibers.Circulation Research, 1982
- Inorganic phosphate promotes relaxation of chemically skinned smooth muscle of guinea-pigTaenia coliCellular and Molecular Life Sciences, 1981
- Purifieation of a Soluble, Sodium‐Nitroprusside‐Stimulated Guanylate Cyclase from Bovine LungEuropean Journal of Biochemistry, 1981
- Mechanism of β- adrenergic relaxation of smooth muscleNature, 1979
- Sodium nitroprusside and other smooth muscle-relaxants increase cyclic GMP levels in rat ductus deferensNature, 1977
- The dependence of contraction and relaxation of muscle fibres from the crab Maia squinado on the internal concentration of free calcium ionsBiochimica et Biophysica Acta (BBA) - Specialized Section on Biophysical Subjects, 1964