Mechanism of β- adrenergic relaxation of smooth muscle
- 1 January 1979
- journal article
- research article
- Published by Springer Nature in Nature
- Vol. 277 (5691) , 32-36
- https://doi.org/10.1038/277032a0
Abstract
The mechanism of .beta.-adrenergic relaxation was investigated in isolated Bufo marinus smooth muscle cells. .beta.-Adrenergic agents [in this case isoprenaline] stimulate cyclic AMP-dependent protein phosphorylation, enhance Na+/K+ transport and induce relaxation. The stimulation of Na+/K+ transport is obligatory for relaxation; this stimulation induces relaxation through enhanced Na+/Ca2+ exchange.Keywords
This publication has 35 references indexed in Scilit:
- Stimulation of cardiac sarcolemmal (Na+ K+)ATPase activity by phosphorylase kinaseEuropean Journal of Pharmacology, 1977
- Isometric contractile properties of single isolated smooth muscle cellsNature, 1977
- β-adrenergic effect on Na+-K+ transport in rat skeletal muscleBiochimica et Biophysica Acta (BBA) - Biomembranes, 1977
- Effects of Potassium Chloride and Smooth Muscle Relaxants on Tension and Cyclic Nucleotide Levels in Rat MyometriumCanadian Journal of Physiology and Pharmacology, 1975
- Protein PhosphorylationAnnual Review of Biochemistry, 1975
- Isolation and characterization of the components of the sodium pumpQuarterly Reviews of Biophysics, 1974
- Na—Ca exchange and tension development in arterial smooth musclePhilosophical Transactions of the Royal Society of London. B, Biological Sciences, 1973
- The action of catecholamines on guinea-pig taenia coliPhilosophical Transactions of the Royal Society of London. B, Biological Sciences, 1973
- Adrenergic influences on uterine smooth musclePhilosophical Transactions of the Royal Society of London. B, Biological Sciences, 1973
- The ionic fluxes in frog muscleProceedings of the Royal Society of London. B. Biological Sciences, 1954