MIDAZOLAM AS AN INDUCTION AGENT IN CHILDREN - A PHARMACOKINETIC AND CLINICAL-STUDY

  • 1 July 1987
    • journal article
    • research article
    • Vol. 66  (7) , 625-628
Abstract
The pharmacokinetics of midazolam was studied in 21 children undergoing elective surgery at five different dose levels for induction of general anesthesia and were compared with a control group (n = 6) given thiopental, 5 mg/kg. The clearance of midazolam was found to be dose-related. The elimination half-life varied from 0.79 to 2.83 hr, which is shorter than in adult patients. Even a dose of 0.6 mg/kg midazolam was found to be unreliable as an agent for induction of anesthesia. Compared with thiopental 5 mg/kg, significantly longer times of onset to closing of the eyes (P < 0.01) and the disappearance of eyelid reflex (P < 0.01) were seen with midazolam.

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