Antimycobacterial physalins from Physalis angulata L. (Solanaceae)

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Abstract
Crude extracts and fractions from aerial parts of Physalis angulata have been bioassayed for antimycobacterial activity. Fraction A1‐29‐12 containing physalins B, F and D exhibited a minimum inhibitory concentration value (MIC) against Mycobacterium tuberculosis H37Rv strain of 32 μg/mL. Purified physalin B and physalin D were also tested showing MIC values against Mycobacterium tuberculosis H37Rv strain of >128 μg/mL and 32 μg/mL respectively, suggesting that physalin D plays a relevant role in the antimycobacterial activity displayed. Structural elucidation of both physalins D and B was based on detailed 13C and 1H NMR spectral analysis with the aid of 2D‐correlation spectroscopy (1H‐1H, COSY, HSQC and HMBC). The assignment of the 13C chemical shift for physalin D is reported here for the first time. Copyright © 2002 John Wiley & Sons, Ltd.
Funding Information
  • FAPESP
  • Universidade de Ribeirao Preto, UNAERP