Effects of Sodium Nitroprusside on Function of Regional Ischemic Myocardium

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Abstract
In dogs with regional myocardial ischemia, administration of nitroprusside caused a 20% decrease in systemic arterial pressure, 25% decrease in coronary perfusion pressure occurring with normal left ventricular end-diastolic pressures. This pressure decrement resulted in a significant decrease in fiber shortening velocity of the ischemic segment during ventricular ejection. A 21% arterial pressure drop after nitroprusside infusion during ischemia in animals with elevated diastolic pressures caused a 28% decrease in coronary perfusion pressure, but resulted in a simultaneous increase in fiber shortening velocity. There was no significant change in stroke volume in any of these animals. Of the 11 animals with increased stroke volume, fiber shortening velocity increased in 4. An increase in stroke volume does not infer a parallel increase in performance of ischemic tissue. Nitroprusside appears to improve regional myocardial performance only in the presence of severe failure.

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