TNF‐α acts via p38 MAPK to stimulate expression of the ubiquitin ligase atrogin1/MAFbx in skeletal muscle
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Open Access
- 20 December 2004
- journal article
- research article
- Published by Wiley in The FASEB Journal
- Vol. 19 (3) , 362-370
- https://doi.org/10.1096/fj.04-2364com
Abstract
Atrogin1/MAFbx is an ubiquitin ligase that mediates muscle atrophy in a variety of catabolic states. We recently found that H2O2 stimulates atrogin1/MAFbx gene expression. Since the cytokine tumor ne...Keywords
Funding Information
- National Institutes of Health (AR049022, HL59878, HL58081, HL61543, HL42250-10/10, GM59203)
- National Space Biomedical Research Institute
- Muscular Dystrophy Association
This publication has 47 references indexed in Scilit:
- The IGF-1/PI3K/Akt Pathway Prevents Expression of Muscle Atrophy-Induced Ubiquitin Ligases by Inhibiting FOXO Transcription FactorsMolecular Cell, 2004
- Induction of MafBx and Murf ubiquitin ligase mRNAs in rat skeletal muscle after LPS injectionFEBS Letters, 2003
- TNF‐α increases ubiquitin‐conjugating activity in skeletal muscle by up‐regulating UbcH2/E220kThe FASEB Journal, 2003
- Sublethal Hemorrhage Induces Tolerance in Animals Exposed to Cecal Ligation and Puncture by Altering p38, p44/42, and SAPK/JNK MAP Kinase ActivationSurgical Infections, 2003
- SB 203580 is a specific inhibitor of a MAP kinase homologue which is stimulated by cellular stresses and interleukin‐1Published by Wiley ,2000
- Oxidative stress in muscular atrophyPublished by Elsevier ,2000
- PD 098059 Is a Specific Inhibitor of the Activation of Mitogen-activated Protein Kinase Kinase in Vitro and in VivoJournal of Biological Chemistry, 1995
- Sepsis-induced myofibrillar protein catabolism in rat skeletal muscleLife Sciences, 1994
- Tumour necrosis factor‐α increases the ubiquitinization of rat skeletal muscle proteinsFEBS Letters, 1993
- Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4Nature, 1970