Rapid Adaptation of Pancreatic Enzyme Secretion in the Conscious Rat

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Abstract
Pancreatic protein composition in basal and stimulated pancreatic juice was studied in conscious rats with cannulated pancreatic ducts. The animals were fed with 3 different diets for 14 days. Secretion rate was stimulated by acute derivation of the juice, intravenous infusion of cerulein and intraduodenal infusions of either amino acids, fat or carbohydrate. In the juice the amount of secretory proteins was measured. The various secretory stimuli did not lead to any rapid change of composition of the secreted enzymes. A so-called ‘nonparallel secretion’ of pancreatic enzymes could not be found in the conscious rat.