Two Compound Replication Origins in Saccharomyces cerevisiae Contain Redundant Origin Recognition Complex Binding Sites
Open Access
- 1 April 2001
- journal article
- research article
- Published by Taylor & Francis in Molecular and Cellular Biology
- Vol. 21 (8) , 2790-2801
- https://doi.org/10.1128/mcb.21.8.2790-2801.2001
Abstract
While many of the proteins involved in the initiation of DNA replication are conserved between yeasts and metazoans, the structure of the replication origins themselves has appeared to be different. As typified by ARS1, replication origins inSaccharomyces cerevisiae are S. cerevisiae replication origins, ARS101 and ARS310, which differ from the paradigm. These origins contain multiple, redundant binding sites for the origin recognition complex. Each binding site must be altered to abolish origin function, while the alteration of a single binding site is sufficient to inactivate ARS1. This redundant structure may be similar to that seen in metazoan origins.Keywords
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