High‐field proton magnetic resonance spectroscopy of human cerebrum obtained during surgery for epilepsy
- 1 September 1989
- journal article
- research article
- Published by Wolters Kluwer Health in Neurology
- Vol. 39 (9) , 1197
- https://doi.org/10.1212/wnl.39.9.1197
Abstract
We analyzed specimens of histologically normal human cerebrum obtained at surgery for medically refractory epilepsy using proton magnetic resonance spectroscopy. Perchloric acid extracts of anterolateral temporal lobe cortex contained greater concentrations of creatine, N-acetylaspartate, γ-aminobutyric acid, alanine, and glutamate than the underlying white matter, which contained more acetate. Frontal and temporal lobe specimens composed of both gray and white matter failed to show statistically significant differences in the concentrations of creatine, N-acetylaspartate, alanine, aspartate, γ-aminobutyric acid, glutamate, glycine, taurine, threonine, valine, acetate, choline, β-hydroxybutyric acid, inositols, lactate, pyruvate, or succinate.This publication has 5 references indexed in Scilit:
- High‐Resolution Proton Magnetic Resonance Spectroscopy of Rabbit Brain: Regional Metabolite Levels and Postmortem ChangesJournal of Neurochemistry, 1988
- Observation of metabolites in the human brain by MR spectroscopy.Radiology, 1986
- A postmortem study of amino acid neurotransmitters in Alzheimer's diseaseAnnals of Neurology, 1986
- Neurometabolic effects of an inborn error of amino acid metabolism demonstrated in vivo by 1H NMRMagnetic Resonance in Medicine, 1986
- A Gas Chromatographic Method for the Determination of N‐Acetyl‐l‐Aspartic Acid, N‐Acetyl‐α‐ Aspartylglutamic Acid and β‐Citryl‐l‐Glutamic Acid and Their Distributions in the Brain and Other Organs of Various Species of AnimalsJournal of Neurochemistry, 1981