S100a0 (αα) Protein Is Present in Neurons of the Central and Peripheral Nervous System

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Abstract
The cellular distribution of S100 subunits in human brain and peripheral nerves was studied by means of an immunohistochemical technique using antibodies specific to the a subunit or the β subunit of S100 protein. The results indicate that the distribution of the a subunit and the β subunit is different among cell types in the nervous tissue, and that neurons in the brain and peripheral nerves contain only the a subunit, or S100a0 protein. The subunit distribution also appears to be different at an intracellular level, where the immunoreaction products for the a subunit show granular arrangement whereas those for the β subunit are found diffusely in the cytoplasm.