Rapid screening of organosulfur agents for potential chemopreventive activity using the murine NA assay
- 1 January 1989
- journal article
- other
- Published by Taylor & Francis in Nutrition and Cancer
- Vol. 12 (2) , 189-193
- https://doi.org/10.1080/01635588909514017
Abstract
The chemopreventive efficacy of 11 organosulfur compounds was assessed using the murine nuclear aberration (NA) assay in C57BL/6J mice. The sulfur compounds were introduced by stomach gavage. Benzo[a]pyrene (BP), which is a carcinogen known to a) undergo biotransformation bypath ways mediated by P‐450 and b) induce NA in the intestine, was used as the challenge. All animals were killed 48 hours after BP injection, and NA per crypt were scored. The results indicated that several agents were active in inhibiting BP nucleotoxicity to the colon, most notably, allyl mercaptan, benzyl mercaptan, and phenylethyl mercaptan. The NA assay was useful in effectively prescreening certain compounds for potential interactions with chemical carcinogens, thus serving as one indicator of chemopreventive activity.Keywords
This publication has 13 references indexed in Scilit:
- Effects of organosulfur compounds from garlic and onions on benzo[a]pyrene-induced neoplasia and glutathione S-transferase activity in the mouseCarcinogenesis: Integrative Cancer Research, 1988
- Diallyl sulfide, a flavor component of garlic (Allium sativum), inhibits dimethyihydrazine-induced colon cancerCarcinogenesis: Integrative Cancer Research, 1987
- Induction of NAD(P)H:quinone reductase in murine hepatoma cells by phenolic antioxidants, azo dyes, and other chemoprotectors: a model system for the study of anticarcinogens.Proceedings of the National Academy of Sciences, 1986
- Effects of allyl methyl trisulfide on glutathioneS‐transferase activity and BP‐induced neoplasia in the mouseNutrition and Cancer, 1986
- Diallyl sulfide A naturally occurring thioether that inhibits carcinogen-induced nuclear damage to colon epithelial cells in vivoMutation Research Letters, 1985
- Inhibition by plant phenols of benzo[a]pyrene-induced nuclear aberrations in mammalian intestinal cells: A rapid in vivo assessment methodFood and Chemical Toxicology, 1985
- The genusallium. Part 2C R C Critical Reviews in Food Science and Nutrition, 1985
- A hypothesis for dietary components as blocking agents of chemical carcinogenesis: Plant phenolics and pyrrole pigmentsNutrition and Cancer, 1985
- Analysis of polycyclic aromatic hydrocarbons in UK total dietsFood and Chemical Toxicology, 1983
- The role of sulfur compounds in food flavor part III: ThiolsC R C Critical Reviews in Food Science and Nutrition, 1976