Ro 22-5417, a new clavam antibiotic from Streptomyces clavuligerus. II. Fermentation, isolation and structure.
- 1 January 1983
- journal article
- research article
- Published by Japan Antibiotics Research Association in The Journal of Antibiotics
- Vol. 36 (3) , 213-216
- https://doi.org/10.7164/antibiotics.36.213
Abstract
The purification of a new antibiotic, Ro 22-5417, was achieved by a variety of preparative column chromatographic methods. The antibiotic was obtained crystalline with an overall recovery of 3% after a 300-fold purification. The structure, determined from proton and 13C NMR spectra, is 3-(7-oxo-1-aza-4-oxabicyclo[3.2.0]hept-3-yl)alanine.This publication has 3 references indexed in Scilit:
- Ro 22-5417, a new clavam antibiotic from Streptomyces clavuligerus. III. Absolute stereochemistry.The Journal of Antibiotics, 1983
- Ro 22-5417, a new clavam antibiotic from Streptomyces clavuligerus. I. Discovery and biological activity.The Journal of Antibiotics, 1983
- Structures of three novel β-lactams isolated from Streptomyces clavuligerusJournal of the Chemical Society, Chemical Communications, 1979