Ro 22-5417, a new clavam antibiotic from Streptomyces clavuligerus. I. Discovery and biological activity.

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Abstract
S. clavuligerus NRRL 3585, a culture which produces a variety of .beta.-lactam antibiotics in the penicillin, cephalosporin and clavam families, produced a new .beta.-lactam antibiotic Ro 22-5417. The compound, which was neither a substrate for nor inhibitor of several .beta.-lactamases, showed antimicrobial activity in defined minimal medium but little or no inhibitory activity in nutrient-rich medium. The activity was bacteriostatic against Bacillus sp. ATCC 27860 and was antagonized by D- and L-methionine, L-cystathionine, L-homocystine and O-acetyl-L-homoserine but not by L-homoserine, L-aspartate, L-cysteine or other common amino acids, vitamins and nucleosides. Apparently, Ro 22-5417 is an inhibitor in methionine biosynthesis.