THE LONG‐TERM HYPOTENSIVE EFFECT OF TIMOLOL MALEATE COMPARED WITH THE EFFECT OF PILOCARPINE IN SIMPLE AND CAPSULAR GLAUCOMA

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Abstract
The long term intraocular pressure (IOP) lowering effect of a .beta.-adrenergic blocking agent, timolol maleate, in topical administration was compared with the effect of pilocarpine on simple and capsular glaucoma by diurnal pressure curves during a 6 mo. follow-up. In simple glaucoma timolol was more effective than pilocarpine in lowering IOP. In the follow-up a significant but not marked increase of the IOP was seen. In capsular glaucoma timolol was not effective enough but when co-administered with miotics the IOP lowering effect was better than with either substance alone. Timolol induced no accomodative myopia, miosis, reduction of tear flow or other side effects. It increased the outflow facility in simple glaucoma but not in capsular glaucoma. During the trial, the anterior chamber depth increased while the corneal thickness remained unchanged. Out of the 6 eyes included in a previous report of secondary glaucoma due to chronic uveitis 4 are still, after 1 yr of therapy, controlled with timolol.

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