Nalidixic Acid, Oxolinic Acid, and Novobiocin Inhibit Yeast Glycyl- and Leucyl-Transfer RNA Synthetases
- 24 July 1981
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 213 (4506) , 455-456
- https://doi.org/10.1126/science.7017932
Abstract
Nalidixic acid and novobiocin inhibit the aminoacylation and pyrophosphate exchange activities of glycyl- and leucyl-transfer RNA synthetases from bakers' yeast. Similar types of inhibition are observed for both enzymes, suggesting similar mechanisms. The potency of these inhibitors is comparable to that observed for their inhibition of in vivo DNA synthesis in eukaryotic cells.This publication has 13 references indexed in Scilit:
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