The Ca2+ antagonist activity of lignans.
- 1 January 1986
- journal article
- letter
- Published by Pharmaceutical Society of Japan in CHEMICAL & PHARMACEUTICAL BULLETIN
- Vol. 34 (8) , 3514-3517
- https://doi.org/10.1248/cpb.34.3514
Abstract
A number of lignans, including those isolated from Arctium lappa (Compositae), were subjected to Ca2+ antagonist assay. The most potent activity occurred in trachelogenin, the calculated Ic50 and pA2 of which were 1.1 .times. 10-6 M and 6.60 respectively. Trachelogenin had a potent and long-lasting antihypertensive effect on spontaneously hypertensive rats.This publication has 2 references indexed in Scilit:
- Antihypertensive effect of cardiovascular Ca2+-antagonist in hypertensive patients in the absence and presence of beta-adrenergic blockadeAmerican Heart Journal, 1978
- On the Constituents of the Fruit of Arctium lappaYAKUGAKU ZASSHI, 1976