VITAMIN D METABOLITES AND THEIR RELATIONSHIP TO AZOTAEMIC OSTEODYSTROPHY*

Publisher Website
Google Scholar
Abstract
Bone biopsies were performed and serum concentrations of vitamin D metabolites were measured in 24 patients with chronic renal failure. The concentrations of 3 metabolites.sbd.25-dihydroxyvitamin D (25-OHD), 24,25-dihydroxyvitamin D (24,25-OH2D) and 1,25-dihydroxyvitamin D (1,25-OH2D).sbd.were significantly lower in uremic than in normal sera. There was a positive correlation between serum 24,25-OH2D and serum 25-OHD; serum 1,25-OH2D values, which were independent of those of the other vitamin D metabolites, were negatively correlated with serum creatinine and serum Pi. The 2 major skeletal lesions, osteomalacia and parathyroid osteopathy, while coexisting in many patients, varied independently in relation to their severity and were correlated with different vitamin D metabolites. The severity of osteomalacia was negatively correlated with the serum concentrations of 24-OHD and 24,25-OH2D while the severity of parathyroid osteopathy was negatively correlated with serum 1,25-OH2D values. Apparently, these are the 1st systematic studies correlating skeletal histology with dihydroxylated vitamin D metabolites in renal failure in man.