Effects of vasoactive intestinal polypeptide on renal function in man.

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Abstract
Six healthy males received vasoactive intestinal polypeptide (VIP; 6 pmol/kg per min) by i.v. infusion for 90 min, with 60 min control periods before and after. Plasma VIP levels rose by .apprx. 100 pmol/l during the infusion. VIP produced changes in heart rate and blood pressure consistent with generalized vasodilatation, but there were no significant changes in effective renal plasma flow or glomerular filtration rate. Both plasma soids and hematocrit rose by .apprx. 5%, suggesting that hemoconcentration had occurred during VIP infusion. Urine flow fell to .apprx. 1/3, and the fractional excretion of Na, K, Cl and Ca fell to between 1/2-2/3 of control values. Fractional excretion of phosphate did not fall significantly. Plasma renin activity rose about 3-fold during VIP infusion.