Evaluation of the Sulphapyridine Acetylator Phenotyping Test in Healthy Subjects and in Patients with Cardiac and Renal Diseases

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Abstract
The acetylator phenotype of 35 healthy, drug-free volunteers and 21 patients with cardiac and/or renal disease was assessed using oral sulfapyridine. Comparative evaluation of a simplified and a more selective method of sulfapyridine analysis was performed. Thirteen of the patients were also phenotyped by determination of plasma isoniazid half-life. Eighty-one percent of the patients were slow acetylators, compared with only 51% of the volunteers. When phenotyping healthy, drug-free subjects, the analytical procedure involving a direct estimation of sulfapyridine in urine, was satisfactory. In patients receiving concomitant drug therapy the more selective analytical procedure was necessary in order to diminish the risk of methodological interference.