WEEKLY CIS-DIAMMINEDICHLOROPLATINUM(II) - ACTIVE 3RD-LINE CHEMOTHERAPY IN OVARIAN-CARCINOMA - A PRELIMINARY-REPORT

  • 1 January 1980
    • journal article
    • research article
    • Vol. 64  (12) , 1379-1382
Abstract
Ten evaluable patients with progressive ovarian adenocarcinoma received 3rd-line chemotherapy consisting of weekly cis-diamminedichloroplatinum(II) at a dose of 1 mg/kg weekly for a maximum of 6 wk followed by 60 mg/m2 every 3 wk. There was no life-threatening toxicity. Seven patients (70%) achieved an objective partial response. This is the highest response rate achieved to date by 3rd-line chemotherapy in women with advanced ovarian adenocarcinoma. Weekly cis-diamminedichloroplatinum(II) therefore warrants a trial as 1st-line therapy.

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