Vasodilator responses to alpha‐human‐atrial natriuretic peptide in isolated omental and pulmonary arteries from rabbit and man

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Abstract
In isolated vessels from the pulmonary and mesenteric/omental arterial circulations of rabbit and man, the effects of synthetic α‐human atrial natriuretic peptide (α‐hANP) were investigated. The vessels had an outer diameter of 0.6–1.2 mm and were contracted by noradrenaline (NA) and prostaglandin (PG) F2α, (mesenteric/omental arteries) or by 5–hydroxytryptamine (5–HT) and PGF2α (pulmonary arteries). It was found that in rabbits, mesenteric vessels contracted by NA and PGF2α were not significantly relaxed by α‐hANP. Rabbit pulmonary vessels contracted by PGF2α or 5–HT were concentration‐dependently relaxed by α‐hANP (maximum 70%). Human omental vessels contracted by NA and PGF2α showed a moderate (30%) relaxation after addition of the peptide. Human pulmonary arteries contracted by 5–HT were relaxed by α‐hANP almost to baseline, while PGF2α‐contracted vessels showed a maximum relaxation of 65%. It is concluced that α‐hANP has a relatively selective effect on pulmonary arterial vessels from rabbit as well as man. The results suggest that the peptide may be involved in the regulation of pulmonary vascular tone.