Cellular Communication in Leukotriene C4 Production between Eosinophils and Neutrophils

1 January 1989

journal article
research article
Published by S. Karger AG in International Archives of Allergy and Immunology

Vol. 90 (1) , 20-23
https://doi.org/10.1159/000234994

Abstract

Eosinophilic granulocytes as well as neutrophilic granulocytes produced leukotriene C₄ (LTC₄) on stimulation with 1 μM A23187 (Ca²⁺ ionophore). In healthy volunteers, the LTC₄ production in eosinophils was about 3 times the production in neutrophils. Within 15 min >90% of the LTC₄ was released into the supernatant. Stimulation of eosinophils and neutrophils together resulted in a synergistic increase in LTC₄ production of 306 ± 40%. LTC₄ synthesis by hypodense eosinophils was also enhanced if stimulated in the presence of neutrophils. These findings suggest a communication between eosinophils and neutrophils, which may play a role in bronchial asthma.

Keywords

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